The first legs dished up some surprises as struggling Liverpool were well beaten by Real Madrid while Paris Saint Germain managed to rally to claim an impressive 3-2 away victory at Bayern.
With only nine games left in the season - 10 if you're Everton - Sportsmail take a look at the key fixtures which could make or break the Champions League hopes of these seven contenders.
But the gap between MLS and Liga MX teams overall continues to close. Eventually an MLS team is going to find the right combination of talent, tactics and luck to pull off a victory in the final.
DANNY MURPHY: There is a good chance we could see three English teams - Chelsea, Liverpool (top), Manchester City (bottom) through to the Champions League semi-finals for the first time since 2009.
This competition has a long history of sides suffering disappointing domestic form raising it when they get to the continent. The stage is set for more of the same this year
Football Nerd: By the end of the season it is highly likely City will have shared the goals around more than any Premier League winner
Man City, Liverpool and Chelsea are flying the flag for the Premier League while Bayern Munich, Paris Saint-Germain and Real Madrid remain strong contenders for the top prize this season.
The Champions League resumes with first-leg matches in the quarterfinals and standing out is the meeting between Bayern Munich and Paris Saint-Germain
LONDON (AP) — The Champions League talking points ahead of the first-leg matches in the quarterfinals: TUESDAY: MANCHESTER CITY VS. BORUSSIA DORTMUND While City could hardly be in better shape
When it is unveiled, the new format for Europe's premier club competition will feature more matches and more money for top clubs.